Advanced Medicinal Chemistry, 5 hp


Course number3FMF0075
Year2023
TypeSubjectcourse
TrackDrug development,
Max participants25
Application deadline2023-10-27
LanguageEn
Course leaderUlrika Rosenström
DepartmentDepartment of Medicinal Chemistry
Visiting addressHusargatan 3
Post addressBox 574, BMC, 751 23 Uppsala
Dates2023-11-06 - 2024-02-09
LocationBMC
Course length
Course report 
Course planCourse plan 

 

Description

This course focuses on advanced medicinal chemistry and, in particular, the design of bioactive molecules towards various macromolecular drug targets such as receptors and enzymes. Strategies for structural modifications/optimizations to enhance pharmacodynamics (PD) and pharmacokinetic (PK) properties are studied in-depth. This also includes the study of physiochemical properties, pharmacophores and structure-activity relationships in general. The different phases of the drug development process are also covered in the course including: identification and validation of drug targets, identification and optimization of active substances, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling of compounds both in vitro and in vivo.

Learning outcomes

On completion of the course, the student should be able to:
• Account for basic principles in medicinal chemistry, including choice of drug target, route of administration and generation of starting points
• Assess the physiochemical properties for drug candidates and execute drug design in regard to target, bioavailability, metabolism, elimination and toxicity
• Describe the different phases of drug discovery and development, and analyse the need for medicinal chemistry in the different phases
• Account for decision points in the drug discovery process from hit/lead to a candidate drug.
• Identify common drug classes based on drug structure

Contents

The course consists of lectures, seminars, workshops, a literature work and oral presentations

Instructions

Basic knowledge about organic molecules and their chemical structure is required to effectively follow the course content

Examination

To pass the course one must take active part in seminars and workshops and receive a passing grade in both the literature work and the oral presentation

Literature

Current scholarly articles as specifically directed

Teaching staff

Ulrika Rosenström
Anders Hallberg
Ulrika Yngve
Johan Wannberg
Anja Sandström
Ulf Bremberg
Ylva Gravenfors

More information

ulrika.rosenstrom@ilk.uu.se

Show all courses 2023 »