Advanced Medicinal Chemistry, 5 hp
| Course number | 3FMF0075 |
| Year | 2023 |
| Type | Subjectcourse |
| Track | Drug development, |
| Max participants | 25 |
| Application deadline | 2023-10-27 |
| Language | En |
| Course leader | Ulrika Rosenström |
| Department | Department of Medicinal Chemistry |
| Visiting address | Husargatan 3 |
| Post address | Box 574, BMC, 751 23 Uppsala |
| Dates | 2023-11-06 - 2024-02-09 |
| Location | BMC |
| Course length | |
| Course report | |
| Course plan | Course plan |
Description
This course focuses on advanced medicinal chemistry and, in particular, the design of bioactive molecules towards various macromolecular drug targets such as receptors and enzymes. Strategies for structural modifications/optimizations to enhance pharmacodynamics (PD) and pharmacokinetic (PK) properties are studied in-depth. This also includes the study of physiochemical properties, pharmacophores and structure-activity relationships in general. The different phases of the drug development process are also covered in the course including: identification and validation of drug targets, identification and optimization of active substances, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling of compounds both in vitro and in vivo.
Learning outcomes
On completion of the course, the student should be able to:
• Account for basic principles in medicinal chemistry, including choice of drug target, route of administration and generation of starting points
• Assess the physiochemical properties for drug candidates and execute drug design in regard to target, bioavailability, metabolism, elimination and toxicity
• Describe the different phases of drug discovery and development, and analyse the need for medicinal chemistry in the different phases
• Account for decision points in the drug discovery process from hit/lead to a candidate drug.
• Identify common drug classes based on drug structure
Contents
The course consists of lectures, seminars, workshops, a literature work and oral presentations
Instructions
Basic knowledge about organic molecules and their chemical structure is required to effectively follow the course content
Examination
To pass the course one must take active part in seminars and workshops and receive a passing grade in both the literature work and the oral presentation
Literature
Current scholarly articles as specifically directed
Teaching staff
Ulrika Rosenström
Anders Hallberg
Ulrika Yngve
Johan Wannberg
Anja Sandström
Ulf Bremberg
Ylva Gravenfors