Advanced cancer biology (3hp), 3 hp
Course number | CB |
Year | 2020 |
Type | Subjectcourse |
Track | Cancer, |
Max participants | 20 |
Application deadline | 2020-04-10 |
Language | En |
Course leader | Femke Heindryckx |
Department | Medical Cell Biology |
Visiting address | BMC, Husargatan 3 |
Post address | Box 571 |
Dates | 2020-06-01 - 2020-06-05 |
Location | |
Course length | 5 days |
Course report |   |
Course plan |   |
Description
The course in advanced cancer biology aims to give a concise overview of important topics in the field of tumor biology. The 5-day course will include both theoretical lectures on different aspects of tumor biology, including: the molecular basis of tumor biology, the tumor microenvironment, clinical oncology and advanced tumor research models. Students will develop skills in critical reading and presentation of relevant literature by attending journal clubs and case discussions. Special attention will be given to advanced models to study tumor cell behavior and to identify therapeutic targets, including 3D in vitro models, bio-printing and mathematical modelling. These topics will be covered via lectures and practical demonstrations in small groups. The course is aimed primarily at PhD students and fits with the research tracks “cancer” and “inflammation”. The course is also open to postdocs and researchers.
Credits: 3 hp (40 course hours + 15 hours preparation + 30 minutes presentation)
Learning outcomes
After the course, the students are expected to:
- Describe the molecular basis of cancer.
- Indicate the role of the tumor micro-environment in tumor progression.
- Outline basic clinical aspects of cancer.’
- Use advanced tumor-biology techniques (such as bio-printing and 3D in vitro models) via on-hands demonstrations.
- Summarize and discuss scientific literature in the field of tumor biology, specifically focusing on the above-mentioned topics
- Criticize and defend research findings in the field of tumor biology.
Contents
The course will cover the following topics:
Molecular and genetic basis of cancer
• Molecular basis of metastasis and invasion
• EMT and cancer stem cells
• Cancer genetics
• Drug resistance
The tumor microenvironment
• The fibrotic stroma
• Onco-immunology
• Angiogenesis in cancer
Advanced research models
• 3D printing and bio-printing
• Mathematical modelling to predict tumor behavior
• In vitro 3D models
• Metabolomics to identify cancer biomarkers
Clinical aspects of cancer research
• The role of Cancerfonden in supporting research
• Pharmacological treatment of cancer
• Radiology and imaging
• Drug discovery in cancer research
Research seminars
• Presentations from participating PhD-students and researchers
Instructions
In addition to mandatory attendance during the course, the students are expected to prepare for journal clubs, give a presentation about their research and to actively participate in discussions.
Examination
To pass, attendance at lectures, oral presentation at the PhD research seminars, and active participation during journal clubs and seminars are required.
Literature
Relevant literature will be provided at the start of the course. This will be in the form of scientific publications and review articles.
Teaching staff
TEACHERS:
Femke Heindryckx
Carlemi Calitz
Paul O´Callaghan
Laia Caja Puigsubira
Yumeng Mao
Stefan Engblom
Fredrik Rorsman
Helena Jernberg Wiklund
And more
More information
Femke Heindryckx, PhD
Medical Cell Biology
Uppsala University
box 571
75123 Uppsala
Sweden